The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial. In a normal lung, the VDaw/Vte ratio is between 25% and 30%. In patients with ARDS, a dead space fraction ≥ 60% was associated with higher mortality ( Kallet RH, Zhuo H, Liu KD, Calfee CS, Matthay MA National Heart Lung and Blood Institute ARDS Network Investigators. A rising VDaw/Vte ratio may be an early sign of ARDS.
The dead space fraction gives you an indication of how effective the ventilation is. An increase in V‘alv can be seen after an effective recruitment maneuver and induces a transient increase in V‘CO2.Ī decrease in V‘alv can indicate that fewer alveoli are participating in the gas exchange, for example, due to pulmonary edema.
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